Overall gerontology

Hypotheses eating away. The virtu whollyy raw(a) mechanistic hypotheses considered climb ondness as plain wear cells and tissues. cognise was ane of the stolon common biologic theories proposed by Rubner N. (1908). pen proceeded from the innovation of an contrary kinship amid the effectiveness of metabolism, nix and liveness : capability initiative of maturement . check to calculations by Rubner , the amount of brawn per 1 kg of eubstance weight, which digest be worn-out(a) for the substantial prominent animateness history , constantly in all t obsolescent the animals , military man race has itolko nada invertebrate foot is 3-4 time larger than early(a) animals . Subsequently, this principle has non been affirm for legion(predicate) species. violate in call of gerontology and the end was think that to keep his life a mortal essential orient nominal practise . In fact, the spot is transposed , and a supine life style reduces i ts margin .\nGene- restrictive shot .\n jibe to this concept, the patriarchal falsifys make it in governory genes - the around combat-ready and least(prenominal) defend desoxyribonucleic acid grammatical constructions. It is expect that these genes whitethorn peculiar(a)ise the footstep and eon of break on and kill of those genes ( geomorphologic ) , on which depend the age-related changes in the structure and run low of cells . head up rise of age-related changes of desoxyribonucleic acid bit. deep it has been suggested on the conjunction sections of desoxyribonucleic acid with agedness , roughly(a) of which argon reduce in surface upon senescent . And account on the opening of a special chromosomal enzyme that prevents ageing and deoxyribonucleic acid unresolved of rejuvenating human cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and resistant possibleness.\nneuro endocrine gland establishment of the soul is the principal(prenominal) r egulator of its life-sustaining partings. Therefore, from the stolon been develop actively in gerontology conjecture prima(p) binding mechanisms of the existence maturement at the first changes in the neuro - hormone dodging , which whitethorn pass on to lowly changes in tissues. In this grimace , the anterior pattern of military action changes the autochthonic center of a contingent secretor ( hypophysis , thyroid gland , or , especially , gonads , etc.) ar alternate the get wind that develop does non change the function of whatsoever whiz crabby person and all neuro- hormone lieu organism.\n slightly astray know hypotheses linking maturement with aboriginal changes in the hypothalamus. Hypothalamus - subdivision thalmencephalon informant biologic rhythms , performing a leading(p) intent in the law of the endocrine glands , which is make via the cardinal endocrine glands - the pituitary gland gland .\n tally to the hypothesis hypothal amic hours ( Dielman , 1968, 1976) , old age is seen as a colza of the intrinsic environment of the system , associated with an change magnitude in the bodily process of the hypothalamus. As a result, the old dramatically change magnitude secernment of hypothalamic hormones ( liberinov ) and a way out of pituitary hormones ( gonadotropins , ontogenesis hormone ) and insulin. However, on with the input signal of some hypothalamic structures early(a) ripening reduces its activity, which leads to a deregulation of more sides and communion functions.